What is Citrin®

In 1991, Citrin was introduced to the health food industry as the first all-natural plant extract standardized for hydroxycitric acid. This unique extract comes from premium, hand-harvested, Garcinia cambogia fruits grown in selected regions of southern India. The active principle of Citrin®, hydroxycitric acid, is in the rind of Garcinia cambogia.

What is HCA?

HCA stands for (-)-hydroxycitric acid. Hoffman-LaRoche, an international pharmaceutical company, and Brandeis University researchers began investigating HCA in the early 1970's. They found that the (-) form of HCA was a potent and competitive inhibitor of citrate lyase, an enzyme found primarily in the liver which is vital in regulating fat metabolism.

How does HCA work?

Fatty acids are the building blocks of fats and lipids. At the cellular level, (-)HCA molecules "trick" the citrate lyase enzyme. The receptor sites of citrate lyase enzymes are filled with (-)HCA. This means fewer fatty acids are synthesized, making less fat available for cellular storage. This results in less body fat build-up in the liver and adipose (fat) tissue. Increased amounts of energy at the cellular level are then available to more rapidly degrade free fatty acids.

Is this all?

No... (-)HCA suppresses appetite thus reducing food intake. When you consume food, the body begins breaking down carbohydrates into glucose (a necessary form of sugar). The liver functions to ensure that the blood continually has adequate glucose to fuel the brain with energy. Excess glucose molecules would normally break down into fat or cholesterol. However, (-)HCA temporarily inhibits the citrate lyase enzyme and excess glucose is converted to glycogen in the liver. When glucose and glycogen reach a certain level, the brain gets a signal of "fullness", suppressing appetite and reducing the desire for more food.
The benefits of (-)HCA found in Citrin® are two-fold:

  • It inhibits the synthesis of fatty acids in the liver, and,
  • It promotes an increased availability of glycogen in the liver, thus sending a "full" signal to the brain sooner.

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